Product Overview

OVA mRNA (modified) encodes ovalbumin (OVA), a classical model antigen widely used in immunology, vaccine research, and protein expression studies.

This modified OVA mRNA incorporates N1-methylpseudouridine (N1-Me-pUTP) modification, which can reduce innate immune activation and improve mRNA stability and translation performance in mammalian cells. It is suitable for applications requiring enhanced protein expression and optimized mRNA performance.

The product is synthesized through in vitro co-transcriptional capping technology and purified using precipitation and desalting methods. The OVA mRNA (modified) has a theoretical length of 1430 nt and supports efficient translation of functional OVA protein in mammalian eukaryotic cells.

It is an ideal tool for antigen expression studies, immune response evaluation, vaccine-related research, and mRNA delivery platform development.

Amino Acid Sequence of Encoded Protein:

MGSIGAASMEFCFDVFKELKVHHANENIFYCPIAIMSALAMVYLGAKDSTRTQINKVVRFDKLPGFGDSIEAQCGTSVNVHSSLRDILNQITKPNDVYSFSLASRLYAEERYPILPEYLQCVKELYRGGLEPINFQTAADQARELINSWVESQTNGIIRNVLQPSSVDSQTAMVLVNAIVFKGLWEKTFKDEDTQAMPFRVTEQESKPVQMMYQIGLFRVASMASEKMKILELPFASGTMSMLVLLPDEVSGLEQLESIINFEKLTEWTSSNVMEERKIKVYLPRMKMEEKYNLTSVLMAMGITDVFSSSANLSGISSAESLKISQAVHAAHAEINEAGREVVGSAEAGVDAASVSEEFRADHPFLFCIKHIATNAVLFFGRCVSP*

Key Features

Efficient OVA Protein Expression

Enables reliable expression of ovalbumin protein in mammalian cells for antigen-related studies and functional assays.

Modified mRNA Technology (OVA mRNA modified only)

Contains N1-methylpseudouridine (N1-Me-pUTP) modification to reduce innate immune recognition and improve translation efficiency.

High Stability and Reliable Performance

• Stable storage performance under recommended conditions

• Tolerates multiple freeze-thaw cycles

• Suitable for various in vitro and in vivo research applications

Quality-Controlled Manufacturing

Produced using optimized in vitro transcription, capping, purification, and quality control processes to ensure batch consistency.

Flexible Supply & Customization Services

Available in multiple package sizes with customization options to support different research requirements.

Applications

OVA mRNA and OVA mRNA (modified) are suitable for a wide range of biomedical research applications, including:

• Antigen presentation and immune response studies

• Evaluation of antigen-specific immune activation

• Vaccine development and immunotherapy research

• mRNA delivery system evaluation

• Cell-based protein expression assays

• In vivo animal model studies

• Research on immune cell activation and regulation mechanisms

Performance Data

Detection of OVA mRNA (modified) Protein Expression by Western Blot Analysis

Stability Testing

Stability of mRNA Bulk Solution at 2–8°C

Demonstrates stable storage performance under refrigerated conditions.

Freeze-Thaw Stability Evaluation

Maintains mRNA integrity and expression activity after repeated freeze-thaw cycles.

Long-Term Stability at -80°C

Supports long-term storage under ultra-low temperature conditions.

FAQ

Q1: What is OVA mRNA used for?

OVA mRNA is commonly used to express ovalbumin protein in cells or animal models for antigen presentation studies, immune response evaluation, vaccine research, and mRNA platform development.

Q2: What is the difference between OVA mRNA and OVA mRNA (modified)?

OVA mRNA (modified) contains N1-methylpseudouridine (N1-Me-pUTP) modification, which can reduce innate immune activation and improve translation efficiency compared with conventional OVA mRNA.

Q3: How should OVA mRNA be stored?

The recommended storage temperature is -85°C to -65°C. Avoid repeated freeze-thaw cycles whenever possible.

Q4: How is the product shipped?

The product can be transported under -45°C to 25°C conditions with appropriate cold-chain protection.

Q5: Are customized mRNA sequences available?

Yes. Customized mRNA design, synthesis, purification, and formulation services are available according to specific research requirements.

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