Resveratrol Powder

Product Overview

Biosynthesized Resveratrol: Green Technology, Defining a New Source

Traditional plant extraction is being upgraded to green biomanufacturing. With synthetic biology and fermentation engineering at the core, we provide a resveratrol solution that is more stable, more environmentally friendly, and better suited for industrial-scale production.

Chemical structure of trans-resveratrol, C14H12O3, CAS 501-36-0

Chemical structure of trans-resveratrol, C₁₄H₁₂O₃, CAS 501-36-0

Product Composition

Item	Description
Chemical Name	Resveratrol (trans-3,5,4′-trihydroxystilbene)
INCI Name	RESVERATROL
Catalog No.	HES0104
Assay / Purity	≥99.0% by HPLC (calculated as trans-resveratrol)
CAS No.	501-36-0
Molecular Formula	C₁₄H₁₂O₃
Molecular Weight	228.24

Manufacturing Process

Item	Description
Method	Biosynthesis (microbial fermentation)
Process Outline	Glucose → strain fermentation → separation → purification → crystallization → drying

Key Features

Why Choose Biosynthesized Resveratrol?

• Green and Sustainable: Reduces reliance on plant resources, lowers solvent use, and minimizes environmental burden.

• Stable Quality: Controllable process parameters ensure high batch-to-batch consistency, supporting standardized production and long-term supply.

• High-Purity Product: Purity ≥99% (HPLC), meeting the needs of various applications.

• More Reliable Supply: Unaffected by seasonal and regional fluctuations of natural raw materials such as grapes and Japanese knotweed (Polygonum cuspidatum), making it suitable for continuous industrial production.

• Better Suited for Brand Upgrading: Aligned with the trends of green manufacturing, low-carbon production, and sustainable supply chains, helping end products stand out in the market.

Resveratrol Synthesis Schematic

Process Features

• Mild reaction conditions

• High selectivity

• Fewer by-products

• Easy scale-up for production

Applications

Where Is Resveratrol Powder Used?

1. Dietary Supplements: Capsules, tablets, powders

2. Functional Foods & Beverages: Fortified foods, health drinks

3. Cosmetics & Personal Care: Anti-aging serums, creams, lotions

4. Pharmaceutical Research: Antioxidant and anti-inflammatory studies

Functions, Directions for Use and Recommended Levels

Item	Description
Main Uses	Dietary supplements, functional foods, cosmetic raw material
Functions	Antioxidant, skin whitening, anti-aging, cardiovascular protection, metabolic regulation
Directions for Use	Oral: take with meals or together with healthy fats (nuts, avocado, etc.) to enhance absorption. Cosmetics: add at room temperature; heating above 40 °C accelerates dissolution; optimal formulation pH range 3.0–6.5; light-protective packaging is recommended, and UV absorbers are advised in daytime skincare products.
Recommended Levels	Oral (general wellness): 10–40 mg/day; guided adult intake 450 mg/day, upper safe level 1000 mg/day. Cosmetics: 0.05%–1.0%.
Incompatibilities	Do not take concomitantly with anticoagulants or antiplatelet drugs (warfarin, aspirin, clopidogrel) or drugs metabolized via CYP3A4/2D6/2C9/1A2. Use with caution in pregnant or lactating women and patients with hormone-sensitive conditions. In cosmetic formulations, avoid strongly alkaline systems (pH > 7), strong oxidizers, and transition-metal ions such as iron.

Performance Data

Specifications and Physicochemical Properties

Item	Description
Appearance	White to off-white needle-like crystalline powder
Odor	Odorless, tasteless
Purity (HPLC)	≥99.0%; assay 99.0–101.5% on dry basis
Typical Batch Result	Purity 100.0%; assay 99.9% (HPLC)
Solubility	Practically insoluble in water; freely soluble in ethanol, acetone, ethyl acetate and other organic solvents
Melting Point	253–257 °C
Stability	Unstable to light and alkali; the trans isomer may isomerize to the cis form under UV irradiation. Stable when kept tightly closed and protected from light.

Heavy Metals: Specification vs. Recent Batch Results

Item	Specification	Recent batch result
Total heavy metals	≤10 ppm	<10 ppm
Arsenic (As)	≤1.0 mg/kg	N.D.
Lead (Pb)	≤0.5 mg/kg	N.D.
Cadmium (Cd)	≤1.0 mg/kg	N.D.
Mercury (Hg)	≤0.1 mg/kg	N.D.

N.D. = not detected.

Testing Methods

Test	Method
Assay, purity, impurity profile (emodin, cis-resveratrol, maximum single impurity, total impurities)	HPLC
Water content	ChP <0832>
Particle size	ChP <0982>
Ash	ChP <2302>
Heavy metals	ChP <0821>
Microbiological limits	ChP <1105>/<1106>
Residual ethanol	GC
Elemental impurities (As, Pb, Cd, Hg)	GB 5009.268

Packaging, Storage and Shelf Life

Item	Description
Packaging	1 kg/bag; 25 kg/drum
Storage	Keep container tightly closed and protected from light; store in a cool, dry place.
Retest Period	2 years (24 months) from the production date under recommended storage conditions
Availability	In stock: quantities up to 4 tons can be shipped promptly
Documents	COA, TDS, MSDS

FAQ

Q1: What Is Resveratrol?

A: Resveratrol is a naturally occurring polyphenolic compound found in various plants, including Japanese knotweed (Polygonum cuspidatum), grape skins, berries, and peanuts. It exists in both cis and trans configurations, but only trans-resveratrol is biologically active. The standardized form used in commercial products is typically trans-resveratrol with a purity of 99% or higher.

Q2: What Is the CAS Number and Molecular Formula of Resveratrol?

A: CAS No.: 501-36-0. Catalog No.: HES0104. Molecular Formula: C₁₄H₁₂O₃. Molecular Weight: 228.24 g/mol.

Q3: What Is the Typical Purity of Your Resveratrol Powder?

A: Our Resveratrol (Catalog No. HES0104) is specified at ≥99.0% purity by HPLC, with assay 99.0–101.5% on dry basis. Typical batch results: purity 100.0% and assay 99.9% by HPLC.

Q4: What Does the Product Look Like?

A: White to off-white or light yellow needle-like crystalline powder; odorless and tasteless.

Q5: What Testing Methods Are Used?

A: HPLC is used for assay, purity, and impurity profiling (emodin, cis-resveratrol, maximum single impurity, and total impurities). Other tests follow Chinese Pharmacopoeia (ChP) methods: water content (ChP <0832>), particle size (ChP <0982>), ash (ChP <2302>), heavy metals (ChP <0821>), and microbiological limits (ChP <1105>/<1106>). Residual ethanol is determined by GC, and elemental impurities (As, Pb, Cd, Hg) by GB 5009.268.

Q6: What Heavy Metal Limits Do You Comply With?

A: Specifications: Total heavy metals ≤10 ppm; Arsenic ≤1.0 mg/kg, Lead ≤0.5 mg/kg, Cadmium ≤1.0 mg/kg, Mercury ≤0.1 mg/kg. Recent batch results: As, Pb, Cd and Hg all not detected (N.D.), total heavy metals <10 ppm.

Q7: What Are the Solubility Characteristics of Resveratrol?

A: Resveratrol is poorly soluble in water (approximately 19–21 mg/L) but freely soluble in ethanol (50 mg/mL), acetone and ethyl acetate, and soluble in DMSO (100 mg/mL) with ultrasonic assistance. This low aqueous solubility is a primary factor limiting its bioavailability. Formulators commonly address this with approaches such as micronization, liposomal delivery, or cyclodextrin complexation.

Q8: How Stable Is Trans-Resveratrol?

A: Trans-resveratrol is stable under acidic conditions (pH < 6.8) but degrades rapidly under alkaline conditions (pH > 6.8). It is also sensitive to light, heat, and oxygen. Exposure to UV or visible light causes isomerization to the less active cis form.

Q9: How Should Resveratrol Be Stored?

A: Store in a tightly sealed, light-resistant container under cool, dry, and dark conditions. Keep away from light, heat and oxygen, as UV exposure may isomerize trans-resveratrol to the less active cis form. Once dissolved, solutions should be prepared fresh or aliquoted and stored at -20°C to -80°C, protected from light, and used within a short period (typically 2 weeks to 6 months depending on conditions).

Q10: What Is the Shelf Life?

A: 24 months (retest period) from the production date under recommended storage conditions (tightly closed, protected from light, cool and dry).

Q11: What Are the Main Application Areas of Resveratrol?

A: Resveratrol is used across multiple industries: Dietary Supplements (capsules, tablets, powders); Functional Foods & Beverages (fortified foods, health drinks); Cosmetics & Personal Care (anti-aging serums, creams, lotions); Pharmaceutical Research (antioxidant and anti-inflammatory studies).

Q12: What Is the Recommended Usage Level of Resveratrol in Cosmetics?

A: In China’s Inventory of Used Cosmetic Ingredients (2021), the maximum historical usage level for leave-on products is 5%. For cosmetic formulations, lower concentrations (recommended 0.05%–1.0%) are commonly used for antioxidant and anti-aging benefits. The optimal formulation pH range is 3.0–6.5; avoid strongly alkaline systems (pH > 7), strong oxidizers, and transition-metal ions such as iron, and use light-protective packaging.

Q13: What Are the Common Side Effects?

A: At typical doses, Resveratrol is generally well tolerated. At higher doses (≥1,000 mg/day), some individuals may experience gastrointestinal discomfort including bloating, nausea, diarrhea, or stomach cramps.

Q14: Is Resveratrol Safe for the Liver?

A: Based on available clinical data, Resveratrol is unlikely to cause clinically apparent liver injury. The LiverTox database classifies it as “E” (unlikely cause of clinically apparent liver injury). Studies using high doses (1.5–3.0 g/day) showed only mild, transient elevations in liver enzymes that resolved upon discontinuation.

Q15: What Packaging Options Are Available?

A: Standard packaging: 1 kg aluminum foil bag, 25 kg fiber drum with inner PE bag. Custom packaging available upon request.

Q16: What Is the Minimum Order Quantity (MOQ)?

A: MOQ varies by product grade and availability. Please contact us for specific requirements.

Q17: Is Bulk Resveratrol Powder in Stock?

A: Yes, Resveratrol is readily available from stock — quantities up to 4 tons are in stock and can be shipped promptly. For larger volumes, please contact our sales team to confirm the lead time.

Q18: Can I Request a Sample?

A: Yes, samples are available for quality evaluation and compatibility testing. Please contact our sales team with your specific requirements.

Q19: What Documents Are Provided?

A: COA, MSDS.