Product Overview

COVID-19 Spike (4000 nt) mRNA encodes the full-length Spike (S) protein of SARS-CoV-2, a critical structural protein involved in viral attachment and host cell entry. The Spike protein is located on the surface of the viral envelope and contains key antigenic regions recognized by the host immune system, making it one of the most widely studied targets in coronavirus research.

The SARS-CoV-2 Spike protein is commonly used in vaccine development studies, immune response evaluation, viral infection mechanism research, and therapeutic candidate screening. Full-length Spike mRNA provides a valuable research tool for studying protein expression, antigen production, and host-pathogen interactions in mammalian cell systems and animal models.

This product is synthesized through in vitro co-transcriptional capping technology and purified by precipitation and desalting processes. With a theoretical length of approximately 4,179 nt, COVID-19 Spike (4000 nt) mRNA enables efficient protein expression in eukaryotic mammalian cells and supports a wide range of molecular biology and translational research applications.

Amino Acid Sequence of Encoded Protein：

MFVFLVLLPLVSSQCVNLTTRTQLPPAYTNSFTRGVYYPDKVFRSSVLHSTQDLFLPFFSNVTWFHAIHVSGTNGTKRFDNPVLPFNDGVYFASTEKSNIIRGWIFGTTLDSKTQSLLIVNNATNVVIKVCEFQFCNDPFLGVYYHKNNKSWMESEFRVYSSANNCTFEYVSQPFLMDLEGKQGNFKNLREFVFKNIDGYFKIYSKHTPINLVRDLPQGFSALEPLVDLPIGINITRFQTLLALHRSYLTPGDSSSGWTAGAAAYYVGYLQPRTFLLKYNENGTITDAVDCALDPLSETKCTLKSFTVEKGIYQTSNFRVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNFNFNGLTGTGVLTESNKKFLPFQQFGRDIADTTDAVRDPQTLEILDITPCSFGGVSVITPGTNTSNQVAVLYQDVNCTEVPVAIHADQLTPTWRVYSTGSNVFQTRAGCLIGAEHVNNSYECDIPIGAGICASYQTQTNSPRRARSVASQSIIAYTMSLGAENSVAYSNNSIAIPTNFTISVTTEILPVSMTKTSVDCTMYICGDSTECSNLLLQYGSFCTQLNRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKDFGGFNFSQILPDPSKPSKRSFIEDLLFNKVTLADAGFIKQYGDCLGDIAARDLICAQKFNGLTVLPPLLTDEMIAQYTSALLAGTITSGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDPPEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKGYHLMSFPQSAPHGVVFLHVTYVPAQEKNFTTAPAICHDGKAHFPREGVFVSNGTHWFVTQRNFYEPQIITTDNTFVSGNCDVVIGIVNNTVYDPLQPELDSFKEELDKYFKNHTSPDVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELGKYEQYIKWPWYIWLGFIAGLIAIVMVTIMLCCMTSCCSCLKGCCSCGSCCKFDEDDSEPVLKGVKLHYT*

Key Features

Full-Length SARS-CoV-2 Spike Protein Encoding

Encodes the complete Spike (S) protein sequence of SARS-CoV-2, providing a comprehensive research model for studying viral antigen expression and immune-related mechanisms.

High Translation Efficiency

Produced using optimized mRNA synthesis technology to achieve efficient protein expression in mammalian cells for in vitro and in vivo research applications.

Excellent Product Stability

• Stable for up to 1 month under recommended storage conditions (2–8℃).

• Maintains performance after more than 10 freeze-thaw cycles.

Reliable Quality and Flexible Supply

• Short lead time to support research timelines.

• Customization services available for different research requirements.

Applications

COVID-19 Spike (4000 nt) mRNA is suitable for:

• SARS-CoV-2 Spike protein expression studies

• Vaccine antigen research and development

• Cellular immune response evaluation

• Viral infection mechanism studies

• Therapeutic candidate screening

• In vitro cell-based assays

• Animal model studies

• mRNA technology development and validation

Performance Data

mRNA Stability at 2–8℃

The product maintains structural integrity and functional activity during refrigerated storage, supporting short-term experimental preparation and transportation requirements.

Freeze-Thaw Stability Evaluation

COVID-19 Spike (4000 nt) mRNA demonstrates strong resistance to repeated freeze-thaw cycles, maintaining reliable performance after more than 10 freeze-thaw cycles.

Long-Term Stability at -80℃

The product maintains stability during long-term frozen storage at -80℃, ensuring consistent performance for extended research applications.

FAQ

Q1: What protein does COVID-19 Spike (4000 nt) mRNA encode?

A: This product encodes the full-length SARS-CoV-2 Spike (S) protein, which is involved in viral-host cell interaction and is widely studied as an antigen target.

Q2: What are the recommended storage conditions?

A: Recommended storage condition is -85℃ to -65℃.

Q3: How should the product be transported?

A: The product supports transportation conditions ranging from -45℃ to 25℃ with appropriate packaging.

Q4: Is customization available?

A: Yes. Customized mRNA sequences and production specifications can be provided according to research requirements.

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