Product Overview
The Blocker Series includes a comprehensive range of active and passive blocking reagents designed to reduce or eliminate assay interference in immunodiagnostic systems.
These products are developed to address common analytical challenges such as:
• Heterophilic antibody interference (HAMA)
• Rheumatoid factor (RF) interference
• Biotin-related assay interference
• Anti-streptavidin antibody (ASA) interference
• Endogenous alkaline phosphatase (ALP) interference
The portfolio covers both Active Blockers (HAMA/RF/broad interference suppression systems) and Passive Blockers (target-specific interference neutralization), providing flexible solutions for ELISA, CLIA, TRFIA, WB, IHC, and rapid diagnostic platforms.
Key Features
Broad Interference Suppression
• Partial or strong inhibition of HAMA (human anti-mouse antibody) interference
• Effective reduction of rheumatoid factor (RF) interference
• Specialized formulations for biotin and streptavidin-related interference
Multiple Blocking Mechanisms
• Heterophilic antibody neutralization (e.g., Mak33, HBR antibody systems)
• Polymer-enhanced blocking performance (Polymer-based blockers)
• Mixed high-polymer systems for enhanced RF suppression
Application-Optimized Formulations
• CLIA-optimized blocker systems for high-sensitivity chemiluminescence assays
• Compatible with immunochromatographic (IC/GICT) rapid test systems
• Designed for ELISA, TRFIA, Western Blot (WB), and IHC workflows
Expanded Interference Control Portfolio
• Biotin interference blocker (Biotin Blocker 01)
• Anti-streptavidin antibody (ASA) inhibition system (Inactive Poly SA)
• Endogenous ALP interference suppression (Inactive ALP)
Ready-to-Use & Scalable Formats
• Liquid-ready reagents for routine diagnostic workflows
• Scalable formulations suitable for assay development and industrial production
Applications
The Blocker Series is widely used in diagnostic assay development and clinical testing systems, including:
• CLIA (Chemiluminescence Immunoassay)
• ELISA (Enzyme-Linked Immunosorbent Assay)
• TRFIA (Time-Resolved Fluorescence Immunoassay)
• WB (Western Blot)
• IHC (Immunohistochemistry)
• IC / GICT (Immunochromatographic rapid tests)
These blockers are especially suitable for assays using mouse-derived antibodies, streptavidin systems, or high-sensitivity detection formats.
Product Portfolio
| Product Series | Product Name | Blocking Characteristics | Application | Notes | Art. No. |
|---|---|---|---|---|---|
| Active Blocker | Heterophilic Antibody Blocker 01 | Inhibit partial HAMA interference、Inhibit RF interference | ELISA，CLIA，TRFIA，WB，GICT | HH6720 | |
| Heterophilic Antibody Blocker 02 | HH6721 | ||||
| Heterophilic Antibody Blocker 03 | HH6722 | ||||
| Blocker 01 | Inhibit HAMA interference and partial RF interference | CLIA | Mak33 | HH6723 | |
| Blocker 01-Polymer | Inhibit partial HAMA interference and RF interference | Mak33 poly HBR-22/23/27 | HH6724 | ||
| Blocker 02 | Inhibit HAMA interference and partial RF interference | IT、IC、CLIA | HBR-5 HBR-1 | HH6725 | |
| Blocker 03 | Inhibit HAMA interference and partial RF interference | CLIA | HBR-5 HBR-1 | HH6726 | |
| Blocker 03-Polymer | Inhibit partial HAMA interference and RF interference | Mak33 HBR-22、HBR-23、HBR-27 | HH6727 | ||
| Blocker 04 | Inhibit HAMA interference and partial RF interference | HBR-5 HBR-1 | HH6728 | ||
| Blocker 05 | Inhibit HAMA interference and RF interference | IT、IC、CLIA | MK33 poly+HBR-5 | HH6729 | |
| Blocker 06 | Inhibit partial HAMA interference and strongly suppress RF interference | CLIA | Mixed high-polymer HBR | HH6730 | |
| Biotin Blocker 01 | Inhibit biotin interference | biotin interference | HH6731 | ||
| Inactive Poly SA | Inhibit anti-streptavidin antibody (ASA) interference | In R&D Phase | |||
| Inactive ALP | Inhibit endogenous ALP interference | CLIA、IHC | In R&D Phase | ||
| Passive Blocker | Mouse Serum IgG | Native mouse IgG passive blocker | ELISA，CLIA，TRFIA，WB，GICT | HH6732 | |
| Mouse IgG | Native mouse IgG passive blocker | HH6733 |
